ROLE OF PROTON PUMP INHIBITORS IN UNCONTROLED ASTHMATIC CHILDREN
Mansour
Abdelsatar Mansour
author
Ehab
Ibrahim Sorour
author
Ahmed
Zaki Mustafa
author
text
article
2017
eng
Introduction: Asthma is a common chronic complex inflammatory airway disorder characterized by variable degrees of recurring symptoms of airflow obstruction and bronchial hyperresponsiveness. The prevalence of symptoms of gastro esophageal reflux among individuals with asthma is substantially higher than in normal population and similarly the prevalence of asthma in individuals with gastro esophageal reflux is also higher than in normal population. Objectives: To identify role of adding proton pump inhibitor to asthma medications of uncontrolled asthmatic children on the level of asthma control. Method: one hundered children with uncontrolled asthma (5 year to 12 years of age), included in our study in the period from october 2014 to june 2016 all of them were regularly followed up in the allergy clinic of alhussien university hospital and devided into to equal groups (study and control) with adding proton pump inhibitor to the study group with asthma medications and follow up the level of asthma control within 3monthes .Results: 28 patient of the 50 study group taken proton pump inhibitor with asthma medications show significant improvement in the level of asthma control and school achievement and the rest is un affected while only 22 of the 50 control group show improvement by usual ashma medicayions without adding proton pump inhibitor while the rest show deterioration of the level of their control Conclusion: we can add proton pump inhibitor with usual ashma medications to children wih difficulty in controlling asthma recommendation: we recommend futher wider studies wih proton pump inhibitor and other anti reflux medications.
Al-Azhar Journal of Pediatrics
Al-Azhar University, Al-Azhar Pediatric Society
1110-7774
20
v.
2
no.
2017
1747
1760
https://azjp.journals.ekb.eg/article_77322_14299891ec42ac9d0a00e0716cd101ef.pdf
dx.doi.org/10.21608/azjp.2017.77322
COST-EFFECTIVENESS AND OUTCOMES OF DEVICE-INDUCED NEONATAL SEPSIS IN NICU
Atef
El-Sayed Donia
author
Mosallam Mohamed
El-Sayed Nasser
author
Sherif
Mostafa Kamal Reda
author
Wael
Refaat Hablas
author
Ahmed
Farag Sharaby
author
text
article
2017
eng
Introduction: Infants in neonatal intensive care units carry a high risk for nosocomial infections. The mortality rate of infections in this age group is reported as between 10-50%. In Egypt, there is deficiency of information and gap of knowledge on estimation of economic burden of device-associated infection in NICU. Minimizing device utilization rate and improving infection control measures could yield saving of costs, morbidity and mortality.
Aims: 1) To determine device associated infection rates with device utilization. 2) Estimate the direct and indirect costs of hospital stays for every case and for the total unit. 3) Determine morbidity and mortality of studied cases.
Patient and Method: This is a descriptive and analytical study done during the period from January 2013 to August 2015; included 140 patients admitted to NICU at El-Hussein University hospital with non-sepsis causes. They were selected by simple random method according to the inclusion and exclusion criteria, with full history, examination and investigations to every case. Divided into two groups, the first device utilization group included 100 cases, and the second non-device utilization group included 40 cases.
Results: Regarding the duration of hospital stay; there was a highly significant increase in first group, also there was a highly significant increase in the duration of hospital stay with multiple devices use. Regarding nosocomial infection; it was significantly higher in the first group, and much more in multiple device use. Regarding costs; the final cost was significantly higher in the first group (432.5 LE per-day), than the second group (352.9 LE per-day). Also the multiple device costs (533.6 LE per-day) was highly significant higher than single device cost (365.2 LE per-day). Total cost during the period of stay for a case in first group (15201.9 LE) was significantly higher than second group (6910.2 LE). About 70% of the first group improved, but morbidity rate was 8% and mortality rates reached 22%; while in the second group there was 95% cure with no mortality rates.
Conclusion:Less aggressive maneuvers and less device insertions mean better outcomes and little expenses in NICU.
Al-Azhar Journal of Pediatrics
Al-Azhar University, Al-Azhar Pediatric Society
1110-7774
20
v.
2
no.
2017
1761
1776
https://azjp.journals.ekb.eg/article_77323_d64f50ba7c9a75fa1b308209db62d92e.pdf
dx.doi.org/10.21608/azjp.2017.77323
THE PREDICTIVE VALUE OF ALPHA 1 ACID GLYCOPROTEIN IN DIAGNOSIS OF NEONATAL SEPSIS
Mohammed Abd El Fatah
Abd Allah
author
Abd El Rahman
Ahmady Awad
author
Hisham Ahmed
Mohammed Ali
author
Ashraf Taha
Abd Elmouttaleb
author
text
article
2017
eng
Background: Neonatal sepsis is an important cause of morbidity and mortality despite the major advances in the management (Stoll, 2004).
Objective: We aimed to evaluate the predictive value of alpha1-acid glycoprotein (alpha1AG) in the early diagnosis of neonatal sepsis.
DESIGN: This case control study was conducted among newborn admitted to neonatal intensive care unit (NICU) of Sayed Galal University Hospital.
Patient And Methods: A total of 90 newborn , 30 with confirmed sepsis by blood culture and laboratory investigation (Group I), 30 with clinically suspected sepsis (Group II), and 30 as a control group (Group III) were enrolled in the study. On admission to NICU, blood was taken for CRP, blood culture, and alpha1AG before starting antibiotic therapy.
Results: We found that serum level of Alpha-1acid glycoprotein was highly significant between clinically suspected septic(Group II) and control groups(Group III) (p=0.00) and highly significant between confirmed septic(Group I) and control groups(Group III) (p=0.00).In the present study the sensitivity, specificity, positive and negative predictive values of alpha 1 acid glycoprotein at cut of value 136ng/ml were found to be 93%, 91.3%, 93.1%, 66.4%, respectively.
Conclusion: Alpha-1-acid glycoprotein has high sensitivity and specificity in early diagnosis of neonatal sepsis.
Al-Azhar Journal of Pediatrics
Al-Azhar University, Al-Azhar Pediatric Society
1110-7774
20
v.
2
no.
2017
1777
1790
https://azjp.journals.ekb.eg/article_77324_0489101cabed756de68736a1cf23d54c.pdf
dx.doi.org/10.21608/azjp.2017.77324
EVALUATION OF WHEAT BRAN INTAKE IN TREATMENT OF INFANT AND CHILDHOOD CONSTIPATION
Hany
A. Samy
author
Khaled
Zayed
author
Ahmed
M. Elsaid
author
text
article
2017
eng
Objectives: The aim of the study was to evaluate the intake of bran and the bowel habit (BH) of constipated children advised a diet containing wheat bran.
Patients and Methods: Bran intake and BH of 51 children with functional constipation defined by the ‘‘Boston criteria’’ were obtained at visit 1 (V1) and at 3 follow-up visits (V2–V4) with median interval of two weeks conducted at Bab-Elshaeria university hospital through the period from May 2017 to December 2017. At each follow-up visit, the BH in the previous 2 weeks was recalled, with questions about frequency, consistency of stool, possible complications (recurrent abdominal pain, enuresis, nonstructural urinary tract infections, and/or fecal soiling) and possible effects of Bran overconsumption (flatulence, abdominal pain/distension, and diarrhea) was obtained.
Results: Median age (range) was 4.75 years (1.12–8.33years); Bran intake and the BH rate significantly increased at V2 and remained higher than at V1 through V2 to V4. 44children accepted bran through visits, at which median bran intake was 20 g/day. Children had significantly higher bran intake at V2 to V4 at which they had improved BH than at those at which they presented unimproved BH. Bran acceptance was associated with improved BH. At the last visit 44 children presented improved BH (86%).
Conclusions: High bran intake is feasible in constipated children and contributes to amelioration of constipation.
Al-Azhar Journal of Pediatrics
Al-Azhar University, Al-Azhar Pediatric Society
1110-7774
20
v.
2
no.
2017
1791
1808
https://azjp.journals.ekb.eg/article_77325_b0ecddb223a95586a7eeb2c7ddc5ae6e.pdf
dx.doi.org/10.21608/azjp.2017.77325
THE ROLE OF GLYCOSYLATED HEMOGLOBIN AND THE PRO-INFLAMMATORY MARKERS (INTERLEUKIN-6 & C-REACTIVE PROTEIN) IN ASSESSING THE SEVERITY OF DIABETIC RETINOPATHY IN PEDIATRICS
Hanan
Abd EL-Moniem Mohamed
author
Mohammed
Bahaa El-Ameer Hawary
author
Ahmed
Fathy Gabr
author
Abdalla
M. El-Ebidi
author
Tereza
Saad Abd El-shahed
author
text
article
2017
eng
Background: Diabetic retinopathy (DR) is one of the vascular complications of diabetes mellitus. It is caused by high blood sugar levels damaging the network of tiny blood vessels that supply blood to the retina. Circulating biomarkers of these pathways such as tumor necrosis factor-α (TNF-α), interleukin–6 (IL-6), C-reactive protein (CRP) in correlation with HbA1C values which reflect the state of glycemic control. Inflammation may be associated with development of both type 1 and type 2 diabetes complications
Objectives: To assess the correlation between the level of pro-inflammatory markers (IL-6, CRP), HbA1c and the severity of the diabetic retinopathy
Patients & Methods: The study was cross sectional study. It conducted on eightypatients. The patients were selected from the Endocrine & Metabolism pediatric Unit at pediatrics Department in Aswan University Hospital during the period from March 2016 to October 2016.
Results: normal fundus examination was found in 74 cases (92.5 %) under 18 years old, while abnormal fundus was detected in 6 cases (7.5 %).IL-6 level in cases with normal fundus examination was (19.72 ± 7.14) and those with abnormal fundus examination was (32.85 ± 9.84) with P. value (0.011). CRP was (9.75 ± 9.5) mg/dl, with P value 0.503 which was insignificant. HbA1c in patients with normal fundus examination was (9.826 ± 1.742 while those of vitreous hemorrhage (9.41 ± 0.1) and those with macular edema (9.79 ± 0.883 %) with P value 0.923 which was insignificant.
Conclusion: There was significant correlation between IL-6 level in diabetic patient and abnormal fundus examination but there is no correlation with CRP level or HbA1c regarding abnormal fundus findings.
Al-Azhar Journal of Pediatrics
Al-Azhar University, Al-Azhar Pediatric Society
1110-7774
20
v.
2
no.
2017
1809
1825
https://azjp.journals.ekb.eg/article_77326_5014ac94ea924eb7a563bdbf2e0b7e7b.pdf
dx.doi.org/10.21608/azjp.2017.77326
CYTOGENETIC STUDY OF CHILDREN WITH DEVELOPMENTAL DELAY AND ASSOCIATED ANOMALIES
Ahmed
Saad
author
Lotfy
Sayed Mohamed
author
Mona
Kamal Mekkawy
author
text
article
2017
eng
Background: Developmental delay (DD) could be syndromic or non-syndromic, and collectively it affects 10% of all children. There are numerous causes of DD that could be genetical, hormonal and/or neurological. The frequency of defected chromosomal anomalies in patients with DD is variable and estimates between 9% and 36%. However, the accurate diagnosis needs further tests based on the information gather from parents and the findings on physical examination.
Objectives: We aim to evaluate the pattern of chromosomal abnormalities in children with DD, in order to detect the treatable cases, and offering an appropriate genetic counseling.
Patients & Methods: This is a cohort study comprised 40 children with developmental delay and associated congenital anomalies were referred from the outpatient clinic of the pediatric department, El Sayed Galal Hospital, to the Human Cytogenetics department, National Research Centre (NRC), Cairo, Egypt. During the period from December 2015 till June 2018.
The patients were subjected to the present study. Peripheral blood samples were collected, cultured, harvested, metaphase spread and then chromosomes were stained for Gbanding using Trypsin-Giemsa technique. Chromosomes were analyzed, metaphase spreads were captured, and karyotyping has been done.
Results: 2 cases out of the 40 affected children have structural chromosomal rearrangements, and 3 out of them carried numerical chromosomal abberations .
Conclusion: Chromosomal studies are valuable in detecting such cases with DD. Prenatal genetic diagnosis is of clinical importance to prevent and offer genetic counseling. Additionally, small proportion of apparently normal population could carry some types of structural chromosomal anomalies.
Al-Azhar Journal of Pediatrics
Al-Azhar University, Al-Azhar Pediatric Society
1110-7774
20
v.
2
no.
2017
1826
1845
https://azjp.journals.ekb.eg/article_77327_a227f022488bcc89c0b1485d18cf18fd.pdf
dx.doi.org/10.21608/azjp.2017.77327