DETECTION AND POTENTIAL UTITITY OF SALIVARY C-REACTIVE PROTEIN FOR DIAGNOSIS OF NEONATAL SEPSIS

doi:10.21608/azjp.2023.325922

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	DETECTION AND POTENTIAL UTITITY OF SALIVARY C-REACTIVE PROTEIN FOR DIAGNOSIS OF NEONATAL SEPSIS
Article 3, Volume 26, Issue 4, October 2023, Page 3615-3629 PDF (214.54 K)
Document Type: Original Article
DOI: 10.21608/azjp.2023.325922
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Abstract
*Objective:* To evaluate salivary CRP as a diagnostic and prognostic biomarker in neonatal sepsis. *Subjects and Methods:* This case-control study included 64 neonates were selected from Ain Sham University Hospital during the period from May 2022 and March 2023 by simple random method, assigned to two equal groups; septic group and a control group. Clinical findings and routine laboratory data including blood culture and complete blood picture results were documented. According to hospital protocol, Serum CRP was measured while salivary CRP levels were measured using enzyme-linked immunosorbent assay. *Results:* The median salivary CRP was significantly higher in septic neonates compared to controls (p < 0.001). For salivary CRP, the optimum cut-off value for sepsis diagnosis was found to be 1.27 mg/L with sensitivity, specificity, positive and negative predictive values of 96.9%, 96.9%, 96.9%, and 100%, respectively. strong positive correlation was found between the levels of salivary and serum CRP (r =.962, p = 0.001). *Conclusion:* Salivary CRP, at a cut-off value of 1.27 mg/L, exhibited a high specificity and positive predictive value in sepsis diagnosis and showed positive correlation with serum CRP.
Keywords
Key words: neonatal sepsis; salivary CRP; serum CRP


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