Neutrophils CD 11b Expression as Biomarker in Early Diagnosis of Neonatal Sepsis

Background: Neonatal sepsis is a major contributor to both mortality as well as mortality in newborns. It is crucial to diagnose and treat the neonate with suspected sepsis at an early stage in order to prevent life-threatening complications.
 Aim: To evaluate the value of neutrophils CD11b for the early diagnosis of neonatal infection and its relation with other laboratory markers such as CBC, hematological scoring system, and CRP and its role as a predictor for outcome in neonatal sepsis.
Patients and methods: This cross-sectional comparative research included 75 newborns at NICUs of the Pediatric Department, Al-Azhar University Hospitals which carried out from October 2023 to August 2024. Neonates divided into 3 groups: Group 1: patients with sepsis (n=25), Group 2: patients with Suspected sepsis (n=25) and Group 3: control group (n=25), Results: Neutrophils CD11b, neutrophils, bands, lymphocytes, as well as CRP, exhibited a statistically significant positive correlation, whereas there was a significant negative correlation among neutrophils CD11b, HB, as well as platelets. Furthermore, a statistically significant positive correlation was observed among neutrophils CD11b and birth weight, Neutrophils CD11b had sensitivity of 98% and specificity of 96% with highly significance for diagnosis of neonatal sepsis., Conclusion: Based on our finding we conclude that, CD11b may be a reliable, rapid and correct biomarker for the early neonatal sepsis recognition and significantly associated with poor risk and prognostic factors of neonatal sepsis. Furthermore, large, multicenter, prospective studies are warranted to support our findings.