Ghaffar, A., Ghanem, S., Metwally, M., Sasy, A. (2019). SERUM MANNOSE BINDING LECTEN IN NEONTAL SEPSIS. Al-Azhar Journal of Pediatrics, 22(2), 221-240. doi: 10.21608/azjp.2019.68840
Ghaffar, A., Ghanem, S., Metwally, M., Sasy, A. (2019). 'SERUM MANNOSE BINDING LECTEN IN NEONTAL SEPSIS', Al-Azhar Journal of Pediatrics, 22(2), pp. 221-240. doi: 10.21608/azjp.2019.68840
Ghaffar, A., Ghanem, S., Metwally, M., Sasy, A. SERUM MANNOSE BINDING LECTEN IN NEONTAL SEPSIS. Al-Azhar Journal of Pediatrics, 2019; 22(2): 221-240. doi: 10.21608/azjp.2019.68840
Background: Mannose-binding lectin (MBL) is a component of innate immunity and particularly important in neonates in whom adaptive immunity is not yet completely developed. MBL deficiency and MBL is associated with an opsonization defect and have been associated with recurrent infections. Objectives: The aim of our study was to determine whether serum MBL levels could serve as markers for predicting neonatal sepsis in neonatal intensive care (NICU). Patients and Methods: This case- control study was conducted on 75 neonates classified into 3 groups: The first group (septic) included 30 neonates who had clinical and laboratory signs of neonatal sepsis.. The second group (suspected) included 30 neonates who had clinical not laboratory signs of neonatal sepsis. The third group (control) included 15 healthy neonates who had no clinical nor laboratory signs of neonatal sepsis ELISA technique was used for measuring MBL serum concentration. Results: Serum MBL levels were significantly lower in the neonates with sepsis or suspected than in the control group. MBL had high sensitivity and specificity values to detect sepsis. Conclusion: MBL serum level could be considered a sensitive and specific marker for prediction of neonatal sepsis. Neonates with significant decrease in MBL are at increased risk for developing sepsis and septic shock.
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