CORRELATION OF METABOLIC ALTERATION IN MAGNETIC RESONANCE SPECTROSCOPY WITH EEG IN DIAGNOSIS OF CHILDHOOD EPILEPSY

Saber, Mahmoud Mohammed; TahaElkeie, Mohsen; AbdElhameid, Iman Ali; Abdul Aziz, Mohamed Said

doi:10.21608/azjp.2019.70123

CORRELATION OF METABOLIC ALTERATION IN MAGNETIC RESONANCE SPECTROSCOPY WITH EEG IN DIAGNOSIS OF CHILDHOOD EPILEPSY

Document Type : Original Article

Authors

10.21608/azjp.2019.70123

Abstract

Background: Epilepsy is a heterogonous group of disorders with multiple causes. It is a common neurologic condition worldwide. Up to 8% of the population will experience at least once seizure in their lifetime.
Objectives: The purpose of this study was to evaluate the potential benefits of MR Spectroscopic image in lateralization of epileptic foci in correlation with EEG and clinical features in the patients with epilepsy.
Methodology: Between December 2016 and August 2018, a total of 50 patients (28 male &22 female) having seizures were selected from the Neurology unite, Pediatric Department, Sayed Galal Hospital, Al Azhar University, underwent to routine video EEG& MRS examination.
Results: 36 patients (72% of total patient number) were found to have abnormal MRS finding. Seven patients (14%) have abnormal finding in both sides. 12 patients (24%) had abnormal data on right side. 17 patient (34%) had abnormal finding on left side. EEG was positive in 34 cases (68%), 14 case (28%) had bilateral findings;12 case (24%) had left sided and 8 cases (16%)had rt sided EEG findings. The temporal region was the commonest epileptogenic area in EEG&MRS. MRS sensitivity to EEG was (79.4%) and specificity was (43.75%) results were nearly consistent with EEG especially in cases with focal EEG discharges.
Conclusion: MRS is a very sensitive noninvasive guiding tool in predicting the lateralization related epilepsy mainly temporal lobe epilepsy rather than generalized epilepsy. It helps in detecting abnormal spectra of various brain metabolites before appearance of structural lesions.
Recommendation: MRS is a very sensitive noninvasive guiding tool in predicting the lateralization related epilepsy mainly temporal lobe epilepsy rather than generalized epilepsy. It helps in detecting abnormal spectra of various brain metabolites before appearance of structural lesions.

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