SERUM GLIAL FIBRILLARY ACIDIC PROTEIN AS BIOMARKER IN NEONATES WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY

Document Type : Original Article

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Abstract

Introduction: Hypoxic ischemic encephalopathy (HIE) is a potentially devastating condition  accounts for 25% of all neonatal deaths , 40% will be affected by blindness, deafness, autism,, epilepsy, or other long-term complications( Felipe et al., 2013).
Aim of work: Assessment of the level of serum glial fibrillary acidic protein (GFAP) in neonate with hypoxic ischemic encephalopathy to early identify neonates with poor prognosis.                                        
Patients and Methods: This study is a case-control study was carried out on 50 neonates babies, they were selected from (NICU) of Bab Elsharia hospital in Cairo during the period from October 2016 to March 2018.
Results: In our study we found that there was statistically significant correlation between GFAP at 24 hours age and this demonstrate a concentration-dependent relationship between serum GFAP at birth and the severity of encephalopathy (Chalak et al. (2014). 
Conclusion: Serial increase in level GFAP from birth in HIE neonates and the severity of the hypoxic-ischemic injury can be stratified at birth and postnatal   because elevated GFAP in serum correlated with severity of HIE.
Recommendations: Measurement of serum GFAP in HIE within 24 hours postnatal but with large sample to early identify neonates with poor prognosis.

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