Abd Allah, M., Ahmady Awad, A., Mohammed Ali, H., Abd Elmouttaleb, A. (2017). THE PREDICTIVE VALUE OF ALPHA 1 ACID GLYCOPROTEIN IN DIAGNOSIS OF NEONATAL SEPSIS. Al-Azhar Journal of Pediatrics, 20(2), 1777-1790. doi: 10.21608/azjp.2017.77324
Mohammed Abd El Fatah Abd Allah; Abd El Rahman Ahmady Awad; Hisham Ahmed Mohammed Ali; Ashraf Taha Abd Elmouttaleb. "THE PREDICTIVE VALUE OF ALPHA 1 ACID GLYCOPROTEIN IN DIAGNOSIS OF NEONATAL SEPSIS". Al-Azhar Journal of Pediatrics, 20, 2, 2017, 1777-1790. doi: 10.21608/azjp.2017.77324
Abd Allah, M., Ahmady Awad, A., Mohammed Ali, H., Abd Elmouttaleb, A. (2017). 'THE PREDICTIVE VALUE OF ALPHA 1 ACID GLYCOPROTEIN IN DIAGNOSIS OF NEONATAL SEPSIS', Al-Azhar Journal of Pediatrics, 20(2), pp. 1777-1790. doi: 10.21608/azjp.2017.77324
Abd Allah, M., Ahmady Awad, A., Mohammed Ali, H., Abd Elmouttaleb, A. THE PREDICTIVE VALUE OF ALPHA 1 ACID GLYCOPROTEIN IN DIAGNOSIS OF NEONATAL SEPSIS. Al-Azhar Journal of Pediatrics, 2017; 20(2): 1777-1790. doi: 10.21608/azjp.2017.77324
THE PREDICTIVE VALUE OF ALPHA 1 ACID GLYCOPROTEIN IN DIAGNOSIS OF NEONATAL SEPSIS
Background: Neonatal sepsis is an important cause of morbidity and mortality despite the major advances in the management (Stoll, 2004). Objective: We aimed to evaluate the predictive value of alpha1-acid glycoprotein (alpha1AG) in the early diagnosis of neonatal sepsis. DESIGN: This case control study was conducted among newborn admitted to neonatal intensive care unit (NICU) of Sayed Galal University Hospital. Patient And Methods: A total of 90 newborn , 30 with confirmed sepsis by blood culture and laboratory investigation (Group I), 30 with clinically suspected sepsis (Group II), and 30 as a control group (Group III) were enrolled in the study. On admission to NICU, blood was taken for CRP, blood culture, and alpha1AG before starting antibiotic therapy. Results: We found that serum level of Alpha-1acid glycoprotein was highly significant between clinically suspected septic(Group II) and control groups(Group III) (p=0.00) and highly significant between confirmed septic(Group I) and control groups(Group III) (p=0.00).In the present study the sensitivity, specificity, positive and negative predictive values of alpha 1 acid glycoprotein at cut of value 136ng/ml were found to be 93%, 91.3%, 93.1%, 66.4%, respectively. Conclusion: Alpha-1-acid glycoprotein has high sensitivity and specificity in early diagnosis of neonatal sepsis.
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