THE ROLE OF GLYCOSYLATED HEMOGLOBIN AND THE PRO-INFLAMMATORY MARKERS (INTERLEUKIN-6 & C-REACTIVE PROTEIN) IN ASSESSING THE SEVERITY OF DIABETIC RETINOPATHY IN PEDIATRICS

Document Type : Original Article

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Abstract

Background: Diabetic retinopathy (DR) is one of the vascular complications of diabetes mellitus. It is caused by high blood sugar levels damaging the network of tiny blood vessels that supply blood to the retina. Circulating biomarkers of these pathways such as tumor necrosis factor-α (TNF-α), interleukin–6 (IL-6), C-reactive protein (CRP) in correlation with HbA1C values which reflect the state of glycemic control. Inflammation may be associated with development of both type 1 and type 2 diabetes complications
Objectives: To assess the correlation between the level of pro-inflammatory markers (IL-6, CRP), HbA1c and the severity of the diabetic retinopathy
Patients & Methods: The study was cross sectional study. It conducted on eightypatients. The patients were selected from the Endocrine & Metabolism pediatric Unit at pediatrics Department in Aswan University Hospital during the period from March 2016 to October 2016.
Results: normal fundus examination was found in 74 cases (92.5 %) under 18 years old, while abnormal fundus was detected in 6 cases (7.5 %).IL-6 level in cases with normal fundus examination was (19.72 ± 7.14) and those with abnormal fundus examination was (32.85 ± 9.84) with P. value (0.011). CRP was (9.75 ± 9.5) mg/dl, with P value 0.503 which was insignificant. HbA1c in patients with normal fundus examination was (9.826 ± 1.742 while those of vitreous hemorrhage (9.41 ± 0.1) and those with macular edema (9.79 ± 0.883 %) with P value 0.923 which was insignificant.
Conclusion: There was significant correlation between IL-6 level in diabetic patient and abnormal fundus examination but there is no correlation with CRP level or HbA1c regarding abnormal fundus findings.

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